Potential drawbacks

There may be some local skin reaction to the cream, including: redness, oedema, skin hardening, vesicles, erosion, ulceration, flaking and scabbing. These brisk inflammatory reactions, at least clinically, would be consistent with an acute immunologic reconstitution of the sun-damaged skin, resulting in an immunologically mediated elimination of malignant and premalignant cells. In all studies, local reactions were common, mostly mild or moderate, were well tolerated by patients, and declined in incidence and severity with less frequent dosing.49-55

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