Relevant outcomes

The most commonly reported therapeutic measure of efficacy is mycological cure, which is defined, by most, as negative light microscopic examination and negative culture. Clinical improvement has been reported in several ways. Some studies have used the parameter of clinical success, which is defined as cleared or markedly improved (90-100% clear nail).33 Others have defined clinical success as cure or improvement sufficient to reduce the involved area of the target nail to less than 25% at the end of therapy.34 Another term used is clinical effectiveness, which is taken to be mycological cure and at least 5 mm of new clear toenail growth.35 Clinical cure refers to the nail after therapy appearing completely cured to the naked eye. Complete cure rate is the combined results of mycological and clinical cure.

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