We found one RCT involving 39 people with DLE and 19 with SCLE, in which hydroxychloroquine, 400-1200 mg/day, was compared with acitretin, 50 mg/day, over 8 weeks,10 described above in the section on hydroxychloroquine. We found three uncontrolled trials of oral retinoids (etretinate or acitretin) in chronic cutaneous lupus. A total of 64 people were treated, and 46 (72%) cleared or experienced marked improvement.89-91
Several case reports report the successful use of retinoids in DLE and SCLE.92-97 We found one case report describing the successful use of topical retinoid in DLE.98
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