Systemic antibiotics Efficacy

We found one systematic review.5 Versus placebo

No placebo-controlled trials of systemic antibiotics were found.

Versus topical antibiotics

Discussed under topical antibiotics above.

Versus each other

Two RCTs compared penicillin and erythromycin, both finding erythromycin to be more effective.20,21 One very small study (n = 18) found no difference between azithromycin and cephalexin.22 A larger study showed equally good results of erythromycin and dicloxacilin.23 Amoxicillin plus clavulanic acid gave better results than amoxicillin alone, but without reaching significance in a small study.24 No differences were found between cefdinir and cephalexin.25 Cephalexin was equal to erythromycin in a small study.20

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