Systemic antifungal therapy for tinea capitis in children

• RCT evidence suggests that griseofulvin for 6-8 weeks is effective and safe for tinea capitis.

• The best evidence available also suggests that terbinafine, itraconazole and fluconazole can cure most patients with tinea capitis with a shorter course of therapy.

• All these drugs have good safety profiles in children.

• Regional as well as dermatophyte species variation may play an important role in the response rate, and may determine what dosage regimens are recommended.

• RCT evidence indicates that terbinafine for 4 weeks is effective and safe for treating Trichophyton spp. tinea capitis.

• Some RCTs suggest that longer ferbinafine therapeutic regimens of 6 weeks are necessary to treat Microsporum spp. infections.

• Some RCT evidence suggests that oral itraconazole for 2-6 weeks is effective and safe to treat tinea capitis in children.

• Limited, mostly observational, evidence suggests that fluconazole for 3-6 weeks is effective and safe for treating tinea capitis in children.

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