Systemic corticosteroids Benefits

Two small RCTs looked at the effects of systemic corticosteroids alone. We found no RCTs comparing systemic corticosteroids with placebo. One trial compared biologically equivalent doses of different corticosteroids: methylprednisolone, 1-17 mg/kg/day, and prednisolone methylsulphobenzoate, 1-16 mg/ kg/day.11 Another trial compared different doses of prednisolone: 0-75 mg/kg/day with

1-25 mg/kg/day.12 Both trials found no statistical difference in effectiveness of treatment.

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