I found no systematic reviews. I found one randomised controlled trial (RCT) of 78 patients treated with tetracycline, 50 mg/day. Improvement was observed at the end of the first month of treatment in 78% of patients. Improvement was also observed in 45% of patients taking placebo.1 In another RCT, 56 patients were treated with "three tablets/day" (presumably of 250 mg each) for 6 weeks. Lesions improved by 78%, compared with 10% in the placebo group.2 In a third RCT, 51 people were treated with tetracycline, 500 mg/day, for 2 months and improved by about 90% (based on scores); similar improvements were seen in the comparison group given 1% metronidazole cream.3 In a controlled clinical trial (CCT) of 101 patients, tetracycline, 750 mg/day, for 2 months cleared lesions in more than 50% of patients.4 An uncontrolled trial compared tetracycline, 1 g/day, for 3 weeks with topical clindamycin. No differences were found.5
Was this article helpful?
Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.