The endemic mycoses

Skin involvement is seen as a consequence of one of three different mechanisms: direct penetration, bloodstream spread from a deep focus, and as an immunological reaction to primary, often respiratory, infection. In the latter instance the skin lesions most commonly seen are erythema nodosum or multiforme.

In the endemic mycoses the usually portal of entry is the lung. Direct entry via inoculation has been proposed in the case of some mycoses such as paracoccidioidomycosis caused by Paracoccidioides brasiliensis where mucocutaneous lesions are common (for example around the nose or mouth). The incidence of pulmonary disease in P. brasiliensis infection, even in the presence of skin lesions, is much higher in the endemic areas, suggesting that widespread subclinical exposure is most likely acquired through the airborne route. The demonstration of dissemination to mucocutaneous areas following fungaemia in animal models and the existence of subclinical pulmonary forms of disease support the view that skin lesions of paracoccidioidomycosis result from dissemination to skin from the lung. This is likely to be true of most cases of systemic endemic mycosis.

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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