The primary aim of treatment of mycetoma is to eradicate the infection and thereby halt the progression of deformity. This is possible in the case of actinomycetomas; however, there is insufficient evidence to support a particular regimen of treatment for eumycetomas, although individual responses have been recorded for ketoconazole, itraconazole and terbinafine and amphotericin B.4 Generally, response rates amongst eumycetoma infections to chemotherapy are low and unpredictable. Therefore, in eumycetoma a secondary objective is to slow the course of the disease thus delaying the time when amputation is necessary. Amputation provides a radical cure.
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