Vitamin D analogues

The vitamin D analogue calcipotriol was introduced in the early 1990s as a topical treatment for mild-to-moderate plaque psoriasis. Since then other vitamin D derivatives have been studied. One systematic review of calcipotriol found that it was at least as effective as potent topical corticosteroids, calcitriol, short-contact anthralin (dithranol) therapy and coal tar. Its main drawback is that it may cause skin irritation. Much less evidence is available for other vitamin D analogues, including tacalcitol and maxacalcitol.

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