Mog21 Gastrointestinal Stromal Tumor

The GIST is the most common mesenchymal tumor that develops in the gastrointestinal tract. Most tumors previously called leiomyoma, schwannoma, leiomyoblastoma, and leiomyosarcoma are classified into a single category of GIST on the basis of molecular, biological, or immunohistological characteristics [1]. We have diagnosed multiple cases of GIST of the small intestine by double-balloon endoscopy.

Figure 10.2.1 shows a case of GIST in which no abnormalities were found by upper or lower gastrointestinal endoscopy performed to investigate repeated melena. The diagnosis was made on the basis of biopsy specimens obtained by double-balloon endoscopy [4]. The endoscopy revealed a rather sharply protruding submucosal tumor with a bleeding ulcer on the top (Fig. 10.2.1a); a similar finding was shown by selective, contrast-enhanced radiography (Fig. 10.2.1b). After a histologically confirmed diagnosis, partial resection of the small intestine was performed (Fig. 10.2.1c).

c Surgical specimen
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