Pathologic Findings Light Microscopy

Mesangial Matrix Expansion

Diabetic nephropathy causes pathologic abnormalities in all of the major structural compartments of the kidney, including the glomeruli, extra-glomerular vessels, interstitium, and tubules (3-10). The earliest glomerular change is enlargement (hypertrophy, hyperplasia, glomerulomegaly), which corresponds to the early clinical phase of elevated glomerular filtration rate. By the time albuminuria is detectable, there is generalized thickening of glomerular basement membranes (GBMs) and an...