Electron Microscopy

The diagnostic lesion consists of irregular thinned and thickened areas of the GBM with splitting and irregular multilaminated appearance of the lamina densa, so-called basket weaving (Fig. 7.1) (2). In between these lamina, granular, mottled material is present. In children with classic Alport's, the GBM may show only thinning rather than thickening. Female carriers of the COL4A5 mutation also show only thin basement mem-

Alport Syndrome
Figure 7.1. The glomerular basement membrane (GBM) is thickened with "basket-weaving" appearance, diagnostic of Alport's syndrome (electron microscopy).

branes, as do carriers of the autosomal recessive form of Alport's. The GBM thickness normally increases with age (12-14). Normal thickness in adults in one series was 373 ± 42 nm in men versus 326 ± 45 nm in women. Glomerular basement thickness <250 nm has been used as a cutoff for diagnosis in many series. In children, the diagnosis of thin basement membranes must be made with caution, establishing normal age-matched controls within each laboratory. In our laboratory, we found a range of GBM thickness in normal children from approximately 110 nm at age 1 year to 222 ± 14 nm in 7-year-olds.

Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook

Post a comment