Electron Microscopy

Electron microscopy reveals no immune complex-type electron dense deposits unless there is concurrent immune complex glomerulonephritis.

Figure 9.3. Glomerulus from a patient with anti-GBM disease showing irregular granular staining of the capillary walls by direct immunofluorescence microscopy using an antibody specific for C3.

Glomerular basement membrane gaps are present in areas of necrosis and crescent formation. Cellular crescents typically contain electron-dense fibrin tactoid strands.

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