Electron Microscopy

Endothelial cells are frequently swollen and detachment may be seen by electron microscopy. Fibrin tactoids may be present in affected glomeruli (Fig. 11.3). Mesangiolysis is a prominent finding in early phases (11).

In the subacute and chronic phase, the increased lucency of the lamina rara interna is in part correlated to breakdown of coagulation products (Fig. 11.4). This zone contains breakdown products of fibrin, laminin, and fibronectin (2).

Figure 11.4. Increased lucency of lamina rara interna and glomerular basement membrane (GBM) corrugation in HUS (electron microscopy).

Figure 11.4. Increased lucency of lamina rara interna and glomerular basement membrane (GBM) corrugation in HUS (electron microscopy).

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