Hyperacute Rejection

Hyperacute rejection occurs when the recipient is presensitized to donor antigens expressed by the endothelium, usually HLA or ABO antigens. Graft dysfunction occurs within minutes to hours of reperfusion, and the grafts generally never function. The pathology is similar to that described for acute humoral rejection, including neutrophils in capillaries, thrombi, and hemorrhage (Fig. 20.9). C4d is generally demonstrable in peritubular capillaries. With ABO incompatibility, IgM is often detectable (Fig. 20.10).

Figure 20.9. Hyperacute rejection. The cortex shows diffuse hemorrhage and neutrophils in peritubu-lar capillaries with prominent glomerular thrombi 1 day after transplantation (H&E stain).

Figure 20.9. Hyperacute rejection. The cortex shows diffuse hemorrhage and neutrophils in peritubu-lar capillaries with prominent glomerular thrombi 1 day after transplantation (H&E stain).

Figure 20.10. Hyperacute rejection due to ABO incompatibility. Immunofluorescence stain shows immunoglobulin M (IgM) in arterial walls.
Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

Get My Free Ebook


Post a comment