Kawasaki Disease

The sine qua non of Kawasaki disease is the mucocutaneous lymph node syndrome, which includes fever, cutaneous, and oral mucosal erythema and sloughing, and lymphadenopathy (11,22). Kawasaki disease is a disease of childhood that rarely occurs after the age of 5 years. The vasculitic lesions of Kawasaki disease involve predominantly small and medium-sized arteries, with a special predilection for the coronary arteries (22). The histologic lesions are characterized by segmental transmural edema and necrosis with infiltration by monocytes and neutrophils (Fig. 9.11). The necrotizing lesions of Kawasaki disease have less fibrinoid material and more edema than the necrotizing lesions of polyarteritis nodosa.

Kawasaki disease rarely causes clinically significant renal disease; however, postmortem examination demonstrates substantial involvement of renal arteritis in many patients who die from Kawasaki disease (22).

The arteritis of Kawasaki disease respond very well to treatment with aspirin and high-dose intravenous immunoglobulin (23).

Figure 9.11. Lobar artery in a postmortem kidney specimen from a patient with Kawasaki disease showing segmental necrosis with associated edema and leukocyte infiltration (H&E).
How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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