Brain Imaging Anomalies

Various methods have been used to assess the brain activity of schizophrenic patients, but the bulk of these studies have not included high-risk children. Nonetheless some relevant findings have emerged. Studies of the P300 event-related brain potential suggest that reduced P300 amplitude is correlated with disturbances in attention, effort, memory and information processing [63], although assessments of P300 amplitude in high-risk patients has yielded mixed results [86]. In a 1992 investigation, auditory event-related potentials (ERPs) distinguished high-risk children from controls and these differences were correlated with high-risk children's performance on a selective listening task [87]. In a review of neuro-behavioural deficits in high-risk children, Erlenmeyer-Kimling [30] reported that children in the New York High-risk Project had no P300 or slow wave differentiation compared with control subjects.

Among discordant monozygotic twins, differences in corpus callosal anterior and middle segmental shape [88], differences in the size of the left anterior hippocampus and right hippocampus, and enlargement of the third and lateral ventricles have been observed [89]. High-risk children also have reduced left amygdala volume, smaller overall brain volume, and enlargement of the third ventricle [90]. Findings from high-risk studies are generally consistent with results seen in adult schizophrenics [30].

BiPolar Explained

BiPolar Explained

Bipolar is a condition that wreaks havoc on those that it affects. If you suffer from Bipolar, chances are that your family suffers right with you. No matter if you are that family member trying to learn to cope or you are the person that has been diagnosed, there is hope out there.

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