Almost every aspect of paediatric bipolar disorder requires more study. Many adolescents and children with bipolar disorder do not respond to current first-line pharmacological treatments. Therefore, studies with novel agents should be extended to this population. Given the poor response in many cases to available treatment, in the face of either lack of efficacy or delayed onset of efficacy of single agents, physicians will continue to use combination therapies. Therefore, the resultant drug-drug interactions also need systematic study.

Factors associated with poor and better outcomes are not clear. The role of temperamental dysregulation in the aetiology of child and adolescent bipolar disorder needs further study. Similarly, the relationship and overlap between borderline personality disorders and bipolar disorder needs further investigation in this age group. Developmentally sensitive measures of comorbidity and specific measures for charting different mood episodes and length of mood episodes are needed. For example, the YMRS scores are higher in younger children and higher in boys [129], for reasons that are not clear. Further research will help clinicians and researchers better understand bipolar disorder in children and adolescents. This in turn will result in more accurate diagnosis and more effective treatment.

Bipolar Disorder Uncovered

Bipolar Disorder Uncovered

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