First Results from Prospective Validation Studies of Early Recognition Inventories and Risk Criteria

Meanwhile, first studies on the risk of transition to psychosis in UHR individuals have been published. Yung et al. [147] identified 20 UHR individuals aged 16 to 30, referred for treatment and followed up at monthly intervals over 6 months. Eight (40%) of these patients developed a frank psychosis. Five of the patients became psychotic as early as the first month. Later studies conducted in larger samples have yielded very similar results for risk periods of one to two years, with the proportion of patients transiting to psychosis ranging from 25% to 41% [74]. A further independent validation of the UHR criteria was done in a control group of UHR cases in a randomized early-intervention study [70]. At one year of follow-up, the rate of transition to psychosis was 35.7% for the controls.

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