At least 50% of children and adolescents suffering from major depression, and 90% of those suffering from bipolar disorder, will continue to suffer from it in adulthood. Pine et al. [51] showed that depressive symptoms in adolescence (even without the existence of major depression) strongly predict a major depressive episode in adulthood. Little is known of the longitudinal outcome of childhood-onset mania. Geller et al. [48] checked the outcome of 89 children with mania and found poor outcome: low recovery rates and high relapse rates compared with adults. They could not rule out the hypothesis that childhood mania responds less well to mood stabilizers. Moreover, prepubertal onset is associated with rapid cycling and worse prognosis [52]. Early-onset and comorbidity cases are expected to suffer from this disorder in adulthood as well [52].

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