There are a number of other features of the neuropathology of schizophrenia, which suggest a fetal insult around mid-gestation. For example, it is known that normal human brain symmetry is determined early in development, during the early second trimester of gestation. Studies have suggested that the left side of the brain is generally more severely affected in schizophrenia than the right,177 and thus that some event occurred during this stage. Similarly, gyrification occurs largely between weeks 16 and 19 weeks of gestation, and sulcal-gyral abnormalities have been found in imaging MRI studies of schizophrenic patients.178'179 Finally, as Clouston himself observed, schizophrenia is associated with an increased risk for other congenital and physical abnormalities, such as cranio-facial abnormalites like cleft palate, which have their origins in mid-gestation.180"183
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