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Neuropathy/Polyneuropathy

The morphology characterized by widespread symmetric axonal involvement in conjunction with sensory and motor symptoms. The disorder corresponds to the pattern of distal axonopathy, where axonal changes primarily involve the distal tract of the longest fibers with the largest diameter of the lower limbs, and, to a lesser degree, the upper limbs (Fig. 18.6a, b - Pinelli 1985).

Alcoholic neuropathy is one of the most common consequences of chronic alcoholism. Although only 9% of 1030 hospitalized alcoholics had clinical

Fig. 18.6a-d. Alcoholic neuropathy and myopathy. a Macro-scopically chronic alcohol intoxication often is characterized by a muscle atrophy of the distal type; b microscopically, in comparison with the normal density of axons in the sural nerve, c a decline of axons is demonstrable; d moreover, a typical distribu tion of atrophic muscle fibers is seen, which is associated with a neurogenic muscle atrophy (symmetric atrophy of small groups of fibers of the lower leg muscles). (b-d Semithin sections; magnification X1000). The figures b-d were kindly provided by Professor Dr. H. Wietholter, Stuttgart

Fig. 18.6a-d. Alcoholic neuropathy and myopathy. a Macro-scopically chronic alcohol intoxication often is characterized by a muscle atrophy of the distal type; b microscopically, in comparison with the normal density of axons in the sural nerve, c a decline of axons is demonstrable; d moreover, a typical distribu tion of atrophic muscle fibers is seen, which is associated with a neurogenic muscle atrophy (symmetric atrophy of small groups of fibers of the lower leg muscles). (b-d Semithin sections; magnification X1000). The figures b-d were kindly provided by Professor Dr. H. Wietholter, Stuttgart symptoms of polyneuropathy (Victor et al. 1971), 93% of them exhibited electromyographic changes (D'Amour et al. 1991; D'Amour and Butterworth 1994). This phenomenon was recently stated by Vittadini et al. (2001) who found polyneuropathies especially in wine-drinkers.

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Alcohol No More

Alcohol No More

Do you love a drink from time to time? A lot of us do, often when socializing with acquaintances and loved ones. Drinking may be beneficial or harmful, depending upon your age and health status, and, naturally, how much you drink.

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