D

Gametes

Gametes

Figure 9.9. Linkage of disease on markers genes, which being closely related segregate together.

Parent

Dffl 1*1 d

Non-recombinants Recombinants

Gametes

Figure 9.10. Breakage of link to form 'recombinants'.

genes are suspected. The discovery of DNA restriction fragment length polymorphisms (RFLPs) has made thousands of different 'anonymous' polymorphic genetic markers available for gene testing.

A3 ferf A3

Figure 9.11. A 'Southern blot' demonstrating loss of one allele (one of a pair) of a likely tumour suppressor gene in DNA from a human cancer.

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