Info

US 2028 091 (American Cyanamid 1936 appl. 1933). US 2 176 423 (American Cyanamid 1939 appl. 1936). US 3 035 973 (Lloyd Brothers Inc. 1962 appl. 1958). drg. 5 mg drinking amp. 50 mg, 100 mg suppos. 10 mg syrup 20 mg 5 ml tabl. 2.5 mg, 5 mg, 50 mg Agaroletten (Warner-Lambert)-comb. Florisan (Boehringer Ing.)-comb. Laxagetten (ct-Arzneimittel)-comb. Otowaxol (Norgine)-comb. Potsilo (Stark, Konstanz)-comb. Tirgon (Woelm)-comb. further combination preparations Norgalax (Norgine Pharma) GB Klyx...

Ci

US 2 895 877 (McNeil 21.7.1959 prior. 30.7.1956). Formulation(s) tabl. 250 mg, 500 mg comb. wfm I Biomioran (Bioindustria) wfm J Chlozoxine (Sanko) Chroxin (Kanto) Framenco (Fuso) Kiricoron (Sampo)-comb. Mesin (Yamanouchi) Nichirakishin (Nichiiko) Pathorysin (Kowa Yakuhin) Rheumadex Comp. (Nakataki)-comb. Salinalon (Nippon Kayaku)-comb. Solaxin (Eisai) Sorazin (Toho) Trancrol (Mohan) Parafon Forte (Ortho-McNeil Pharmceutical)-comb. Use antipruritic at biliary congestion RN 11041-12-6 MF...

Bpv

DRP 223 695 (Byk appl. 1907). stabilized solutions US 4 073 907 (Abbott 14.2.1978 appl. 1.6.1976). Formulation(s) amp. 120 mg ml, 240 mg 10 ml s. r. tabl. 225 mg, 350 mg tabl. 125 mg (as dihydrate) Aminophyllin (OPW) Limptar (Cassella-med)-comb. Phyllotemp (Mundipharma) Theophyllin- Aethylendiamin ratiopharm (ratiopharm) F Aminophylline Lobica (Opodex) wfm Campho-pneumine aminophylline (Merrell)-comb. wfm Cardiophylline (Lefranca)-comb. wfm Inophyline (Millot) wfm Eus dyl aminophylline...

N

DOS 2 057 845 (Bristol-Myers appl. 24.11.1970 USA-prior. 24.11.1969). US 3 976 776 (Mead Johnson 24.8.1976 prior. 24.11.1969). Wu, Y.H. et al. J. Med. Chem. (JMCMAR) 15, 477 (1972). US 3 907 801 (Mead Johnson 23.9.1975 prior. 24.11.1969). US 3 717 634 (Mead Johnson 20.2.1973 prior. 24.11.1969). Trade Name(s) D Bespar (Bristol-Myers 1985) F Buspar (Bristol-Myers Squibb 1988) GB Buspar (Bristol-Myers Squibb 1987) I Axoren (Glaxo Wellcome) Buspar (Bristol It. Sud) USA Buspar (Bristol-Myers Squibb...

Choline salicylateatC N02BA03

(Salicylate de choline) Use analgesic, anti-inflammatory, RN 2016-36-6 MF C5H14NO C7H503 MW 241.29 EINECS 217-948-8 LDS0 2690 mg kg(M, p.o.) US 3 069 321 (Labs. forPharmac. Dev. 18.12.1962 appl. 4.4.1960). BE 583 513 (Mundipharma appl. 12.10.1959). Forrnulation(s) drops 200 mg ml gel 87.1 mg g sol. 500 mg 100 ml Trade Name(s) D Audax (Mundipharma) Givalex (Norgine)-comb. Mundisal (Mundipharma)-comb. F Givalex (Norgine Pharma)- I comb. Pansoral (Inava)-comb. GB Bonjela (Reckitt &...

N N

DE 2 827 497 (ABC appl. 22.6.1978 I-prior. 4.6.1978). US 4 187 308 (ABC 5.2.1980 I-prior. 4.6.1978). Avico, U. et al. Farmaco, Ed. Sci. (FRPSAX) 17, 73 (1962). synthesis o theophylline-7-acetaldehyde Maney, P.V. J. Am. Pharm. Assoc. (JPHAA3) 35, 266 (1946). Toffoli, F. et al. Farmaco, Ed. Sci. (FRPSAX) 11, 516 (1956). Farmulation(s) amp. 100 mg 10 ml cps. 300 mg sachet 200 mg s. r. tabl. 300 mg tabl. 400 mg Trade Name(s) I Ansimar (ABC 1988) RN 23214-92-8 MF C27H29NOn MW 543.53 EINECS 245-495-6...

Oh

US 3 883 505 (Ajinomoto 13.5.1975 J-prior. 17.7.1972). DE2 336 378 (Ajinomoto appl. 17.7.1973 J-prior. 17.7.1972). Chibara, J. et al. Cancer Res. (CNREA8) 30, 2776 (1970). Chihara, G. et al. Nature (London) (NATUAS) 222, 637 (1968). Sasaki, T. et al. Carbohydr. Res. (CRBRAT) 47, 99 (1976). water soluble pharmaceutical formulation US 4 207 312 (Ajinomoto, Morishita 10.6.1980 J-prior. 5.2.1975). EP 326 149 (Green Cross, Morinaga appl. 27.1.1989 J-prior. 29.1.1988). Trade Name(s) J Lentinan...

Nh I

GB 1 177 525 Leo appl. 13.4.1967 valid from 2.4.1968 . DOS 1 770 153 Leo appl. 8.4.1968 GB-prior. 13.4.1967 . GB 1 497 306 Leo appl. 3.7.1975 valid from 30.6.1976 . DOS 2 628 558 Leo appl. 25.6.1976 GB-prior. 3.7.1975 . US 3 637 660 Leo 25.1.1972 appl. 8.4.1968 GB-prior. 13.4.1967 . GB 1 498 857 Leo appl. 3.7.1975 valid from 30.6.1976 . US 4 061 747 Leo 6.12.1977 GB-prior. 3.7.1975 . Eriksoo, E. Rohte, O. Arzneim.-Forsch. ARZNAD 20, 1561 1970 . Formulation s f. c. tabl. 10 mg, 25 mg, 35 mg, 70...

Metaclazepamatc nosba

Brometazepam Metuclazepam Use anxiolytic, benzodiazepine derivative RN 84031-17-4 MF C18H18BrClN20 MW 393.71 LD5 1578 mg kg M, p.o. CN -methyl-1 -1,4-benzodiazepine monohydrochloride RN 61802-93-5 MF C18H18BrClN20 HCl MW 430.17 EINECS 263-234-4 LD50 1578 mg kg M, p.o. I 1 1 1 1 BE 799 001 Kali-Chemie appl. 2.5.1973 D-prior. 3.5.1972 . DOS 2 520 937 Kali-Chemie appl. 10.5.1975 . US 4 098 786 Kali-Chemie 4.7.1978 appl. 23.9.1976 D-prior. 3.5.1972 . US 4 244 869 Kali-Chemie 13.1.1981 D-prior....

Diacereinatc moiax21

RN 13739-02-1 MF C19H1208 MW 368.30 EINECS 237-310-2 LD50 7500 mg kg R, route unreported t,8-dihydroxy-3-hyd roxym ethyl-cnthroquinone e.g. from borboloin t,8-dihydroxy-3-hyd roxym ethyl-cnthroquinone e.g. from borboloin DOS 2 711 493 C. A. Friedmann appl. 16.3.1977 SA-prior. 16.3.1976 . Oesterle, O.A. Arch. Pharm. Weinheim, Ger. ARPMAS 241, 604 1903 . Robinson, R. Simonsen, J.L. J. Chem. Soc. JCSOA9 1909, 1085. Cahn, R.S. Simonsen, J.L. J. Chem. Soc. JCSOA9 1932, 2573. Formulation s cps. 50 mg...

Apy

DE 1 695 201 Hoffmann-La Roche appl. 21.9.1967 CH-prior. 28.10.1966, 24.4.1967, 17.7.1967 . US 3 654 357 Roche 4.4.1972 CH-prior. 26.4.1968 . US 3 787 491 Hoffmann-La Roche 22.1.1974 prior. 29.9.1971 . US 3 860 724 Hoffmann-La Roche 14.1.1975 prior. 29.9.1971 . D Gluborid Griinenthal F Glutril Roche 1972 Glutril ICN 1972 GB Glutril Roche 1975 wfm RN 21187-98-4 MF C15H21Ns03S MW 323.42 EINECS 244-260-5 LD,0 295 mg kg M, i.v. 3 g kg M, p.o. 382 mg kg R, i.V. 3 g kg R, p.o. CN...

Oxycodoneatc N02AA05

RN 76-42-6 MF ClftH2IN04 MW 315.37 EINECS 200-960-2 LD50 320 mg kg M, i.p. 426 mg kg M, s.c. RN 124-90-3 MF C18H2lN04 - HC1 MW 351.83 EINECS 204-717-1 US 5 266 331 Euroceltique 30.11.1993 appl. 27.11.1991 . Formulation s cps. 5 mg s. r. tabl. 10 mg, 20 mg, 40 mg, 80 mg Trade Name s D Eubine Chemipharm Scophedal Merck -comb. GB Proladone Boots wfm Eukodal Merck wfm F Eubine Promedica Percodan Endo -comb. Roxicodone Roxane Tylox Ortho-McNeil generics and combination preparations RN 15687-41-9 MF...

Sku

US 2 685 585 Hoffmann-La Roche 1954 prior. 1951 . Formulation s tabl. 50 mg as phosphate Trade Name s F Marsilid Laphal GB Marsilid Roche wfm Use antihypertensive, angiotensin II antagonist RN 138402-11-6 MF C25H28N60 MW 428.54 CN 2-butyl-3- 2'- l -tetrazol-5-yl 1,1 -en-4-one

Gamolenic acid

A From fermentation of Mortierella. b From fermentation of mucor. c Extration and isolation from natural sources seeds of black currant, evening primrose, borage . a JP59 130 191 Agency of Ind. Sciences and Techn. appl. 12.1.1983 . JP 60 168 391 Agency of Ind. Sciences and Techn. appl. 9.2.1984 . JP 63 112 536 Agency of Ind. Sciences and Techn. appl. 30.10.1986 . WO 8 604 354 Agency of Ind. Sciences and Techn. appl. 13.12.1985 J-prior. 22.1.1985, 21.2.1985 . EP 155 420 Agency of Ind. Sciences...

Pzh

A EP463 756 Pfizer Inc. appl. 7.6.1991 GB-prior. 20.6.1990 . Terrett, N.K. et al. Bioorg. Med. Chem. Lett. BMCLE8 6, 1819-1824 1996 . Palmer, E. Chem. Brit. CHMBAY 1999, 24 b EP 812 845 Pfizer Corp. appl. 4.6.1997 GB-prior. 14.6.1996 . Dale, D.J. et al. Org. Process Res. Dev. OPRDFK 4, 17-22 2000 . preparation of ethyl 3-propylpyrazole-5-carboxylate Terrett, N.K Bell, A.S. Brown, D. Ellis, P. Bioorg. Med. Chem. Lett. BMCLE8 6 15 , 1819 1996 . preparation 0 ethyl 2,4-dioxoheptanoate Lap worth...

Gdn

5-benzoyl-2-chloro-1 5-benzoyl-2-chloro-1 a,bUS4 347 186 Syntex 31.8.1982 appl. 20.10.1980 . US 4 458 081 Syntex 3.7.1984 appl. 11.6.1982 prior. 20.10.1980 . c US 4 873 340 Syntex 10.10.1989 appl. 29.5.1986 . DE 2 760 330 Syntex appl. 13.7.1977 USA-prior. 14.7.1976, 23.2.1977 . DE 2 731 678 Syntex appl. 13.7.1977 USA-prior. 14.7.1976, 23.2.1977 . US 4 087 539 Syntex 5.2.1978 appl. 23.2.1977 prior. 14.7.1976 . US 4 089 969 Syntex 16.5.1978 appl. 23.2.1977 prior. 14.7.1976 23.2.1977 . US 4 097...

Methylmethionine sulfonium chlorideatc a02

Methiosulfonii chloridum MMS Vitamin U Use Peptic ulcer therapeutic, antidote RN 1115-84-0 MF C6H14C1N02S MW 199.70 EINECS 214-231-1 LD50 259 mg kg M, i.v. gt 6 g kg M, p.o. 432 mg kg R, i.v. gt 6 g kg R, p.o. CN chloride RN 33515-11-6 MF C6H14BrN02S MW 244.15 iodide RN 3493-11-6 MF C6H14IN02S MW 291.15 DE 1 239 697 Degussa appl. 20.2.1963 . therapy of renal diseases US 4 122 189 Kaken 24.10.1978 J-prior. 31.3.1976 . GB 1 538 000 Kaken appl. 30.3.1977 J-prior. 31.3.1976 . DOS 2 714 391 Kaken...

Dihydroergotamineatc no2caoi

Use sympatholytic, antimigraine agent RN 511-12-6 MF C33H37N505 MW 583.69 EINECS 208-123-3 LDW 118 mg kg M, i.v. RN 6190-39-2 MF C33H37N505 CH403S MW 679.80 EINECS 228-235-6 LDS0 gt 2g kg M, p.o. gt 2 g kg R, p.o. tartrate 2 1 RN 5989-77-5 MF C H37N,0, l 2C4H606 MW 1317.46 EINECS 227-816-1 LDm 118 mg kg M, i.v. 110mg kg R, i.v. Stoll, A. Hoffmann, A. Helv. Chim. Acta HCACAV 26, 2070 1943 . DE 883 153 Sandoz appl. 1941 CH-prior. 1940 . DOS 2 802 113 Sandoz appl. 19.1.1978 . Formulation s amp. 1...

Cooh

DE 3 128 819 Biorex Lab. appl. 21.7.1981 GB-prior. 21.7.1980, 7.7.1981 . Formulation s cps. 750 mg as disodium salt GB Colazide Astra manuf. by Salix Use p2-receptor agonist, orally active lipophilic terbutaline ester prodrug, long lasting bronchodilator RN 81732-65-2 MF C18H29N305 MW 367.45 CN dimethylcarbamic acid ester monohydrochloride RN 81732-46-9 MF C18H29N305 HCl MW 403.91 I EP 43 807 Draco appl. 30.6.1981 GB-prior. 9.7.1980, 29.5.1981 . DOS 3 163 871 Draco appl. 23.1.1981 GB-prior....

Bucloxic acidATC n02

Acide bucloxique Use anti-inflammatory RN 32808-51-8 MF C16H19C103 MW 294.78 EINECS 251-231-0 LD,0 852 mg kg M, p.o. RN 32808-53-0 MF C32H36CaCl206 MW 627.62 EINECS 251-232-6 LD50 1700 mg kg M, p.o. 175 mg kg R, p.o. 4-oxo-4- 4-cyclohexyl-pheny butyric acid 4-oxo-4- 4-cyclohexyl-pheny butyric acid DE 2 021 445 Clin-Byla appl. 2.5.1970 F-prior. 12.5.1969 . GB 1 315 542 Clin-Byla appl. 7.5.1970 F-prior. 12.5.1969 .

Betneval Neomycin

US 3 312 590 Glaxo 4.4.1967 GB-prior. 11.6.1963, 28.1.1964 . US 3 312 591 Glaxo 4.4.1967 GB-prior. 10.5.1963, 28.1.1964 . DOS 2 055 221 Lab. Chim. Farm. Blasina appl. 10.11.1970 . DOS 2 340 591 Glaxo appl. 10.8.1973 GB-prior. 11.8.1972 . DOS 2 431 377 Lark appl. 29.6.1974 I-prior. 4.1.1974 . ZA 7 700 678 S. Fourie et al. appl. 7.2.1977 . FR-M 5 399 P. Temime appl. 14.10.1965 . BE 829 197 L. Grosjean appl. 16.5.1975 . Formulation s cream 0.1 lotion 0.1 ointment 0.1 tabl. 0.1 mg Trade Name s...

BiperideneATC N04AA

RN 514-65-8 MF C21H29NO MW 311.47 EINECS 208-184-6 LD50 56 mg kg M, i.v. 530 mg kg M, p.o. 750 mg kg R, p.o. 340 mg kg dog, p.o. CN a-bicyclo 2.2.1 hept-5-en-2-yl-a-phenyl-1 -piperidinepropanol RN 1235-82-1 MF C21H2 NO HCl MW 347.93 EINECS 214-976-2 LD50 56 mg kg M, i.v. 530 mg kg M, p.o. 750 rag kg R, p.o. 340 mg kg dog, p.o. lactate 1 1 RN 7085-45-2 MF C21H29NO C3H603 MW 401.55 EINECS 230-388-9 LD30 61 mg kg M, i.v. aldehyde - propiophenone I chloride aldehyde - propiophenone I

1

-methyl-ethyl -N,4-diphenyl-1 H-pyrrole-3-corb-oxamide -methyl-ethyl -N,4-diphenyl-1 H-pyrrole-3-corb-oxamide a,bUS 4 681 893 Warner-Lambert appl. 21.7.1987 USA-prior. 30.5.1986 . EP 409 281 Warner-Lambert appl. 23.1.1991 USA-prior. 21.7.1989, 26.2.1991 . EP 680 320 Warner-Lambert appl. 8.11.1995 USA-prior. 19.1.1993 . c Naeminga, T. et al. Tetrahedron Lett. TELEAY 33, 2279-2282 1992 . WO 9 703 960 Warner-Lambert appl. 6.2.1997 USA-prior. 17.7.1995 . ca Baumann, K.L. et al. Tetrahedron Lett....