Key equation 2 is built from basic equations 3-5. The following definitions are used:
• Rt—total number of receptors
To provide useful information it is necessary to relate receptor occupancy (r) to agonist concentration [D]. To derive key equation 2 the receptor term not featuring in occupancy, [R], must be substituted in key equation 1.
Occupancy is the proportion of receptors occupied by the agonist and this is described by basic equation 3.
Basic Equation 3
In other words, the total number of receptors is the sum of free and drug-bound receptors as given in basic equation 4.
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