This phase describes a brief fall in membrane potential towards zero following the rapid rise in phase 0. This occurs due to the start of potassium flow out of the cell under the positive intracellular electrical gradient and chemical gradients. At the same time slow, L type, Ca2+ channels open, providing a prolonged influx of calcium ions which maintains the positive intracellular charge There is also movement intracellularly of chloride following sodium into the cell along the electrical gradient. This leads to an initial rapid repolarization of the cell membrane to just above 0 mV.
Was this article helpful?
This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.