because of the high luminal Cl- concentration established by * absorption. This occurs mainly by the paracellular route (Figure RE.6c). Na+ then follows passively down its electrical gradient. Up to 20% of NaCl reabsorption in the late proximal tubule occurs by this mechanism. In contrast, Cl- and do not differ in the juxtamedullary nephron tubule.



Figure RE.6b Sodium handling throughout the proximal tubule

Figure RE.6c Sodium handling in the late proximal tubule

Re-Absorption of Other Solutes in the Proximal Tubule

Sodium re-absorption leads to electrical, concentration and osmotic gradients for the re-absorption of such solutes as chloride, potassium and urea, and also for water re-absorption. It is also important for the reabsorption of glucose, amino acids, phosphate and calcium and for the secretion of H+.

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