Left Shift of the ODC

This represents an increase in the affinity of Hb for oxygen in the pulmonary capillaries but requires lower tissue capillary PO2 to achieve adequate oxygen delivery. P50 is reduced by factors causing a left shift, which include:

• Decreased PCO2

• Decreased concentration of 2,3-DPG

• Decreased temperature

• Presence of HbF rather than adult forms of Hb

Figure RR.16 Oxyhaemoglobin dissociation curve

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