Zolpidem is an imidazopyrine that acts at the benzodiazepine receptor complex of the GABAa receptor, to produce anxiolysis and sedation. It is selective for ra1 receptor subtype producing hypnosis without the ataxia or other ra2 effects. The effects are reversed by flumazenil. Zolpidem is rapidly absorbed with a bio-availability of 70%. Concentrations peak at about 1-3 h and it is 93% protein-bound. Zolpidem is metabolized to inactive metabolites in the liver with a half life of 2.4 H.
Was this article helpful?