Contents

Series Editor Page v

Foreword by Ralph Holman, PhD vii

Foreword by William Lands, PhD ix

Preface xvii

Contributors xxiii

Part I Basic Mechanisms

1 Evolutionary Aspects of Diet: Essential Fatty Acids 3

Artemis P. Simopoulos

2 Modulation of Receptor Signaling by Phospholipid Acyl Chain

Composition 23

Drake C. Mitchell and Burton J. Litman

3 Role of Docosahexaenoic Acid in Determining Membrane

Structure and Function: Lessons Learned from Normal and Neoplastic Leukocytes 41

Laura J. Jenski and William Stillwell

4 Effects of Essential Fatty Acids on Voltage-Regulated

Ionic Channels and Seizure Thresholds in Animals 63

Robert A. Voskuyl and Martin Vreugdenhil

5 Role of Dietary Fats and Exercise in Immune Functions and Aging 79

Jaya T. Venkatraman and David Pendergast

Part II Phospholipid and Fatty Acid Composition and Metabolism

6 On the Relative Efficacy of a-Linolenic Acid and Preformed Docosahexaenoic Acid as Substrates for Tissue Docosahexaenoate

During Perinatal Development 99

Meng-Chuan Huang and J. Thomas Brenna

7 Recent Advances in the Supply of Docosahexaenoic Acid to the Nervous System 115

Robert J. Pawlosky and Norman Salem Jr.

8 Quantifying and Imaging Brain Phospholipid Metabolism

In Vivo Using Radiolabeled Long Chain Fatty Acids 125

Stanley I. Rapoport

9 Carbon Recycling: An Important Pathway in a-Linolenate

Metabolism in Fetuses and Neonates 145

Stephen C. Cunnane

Part III DHA and CNS Development

10 Impact of Dietary Essential Fatty Acids on Neuronal Structure and Function 159

M. Thomas Clandinin, R.A.R. Bowen, and Miyoung Suh

11 Dietary N-3 Fatty Acid Deficiency and its Reversibility:

Effects upon Brain Phospholipids and the Turnover of Docosahexaenoic Acid in the Brain and Blood 177

William E. Connor, Gregory J. Anderson, and Don S. Lin

12 The Role of Omega-3 Polyunsaturated Fatty Acids in Retinal Function 193

Algis J. Vingrys, James A. Armitage, Harrison S. Weisinger,

B.V. Bui, Andrew J. Sinclair, and Richard S. Weisinger

13 Brightness-Discrimination Learning Behavior and Retinal Function Affected by Long-Term a-Linolenic Acid Deficiency in Rat 219

Harumi Okuyama, Yoichi Fujii, and Atsushi Ikemoto

Part IV Pathology

14 Disturbances of Essential Fatty Acid Metabolism in Neural Complications of Diabetes 239

Joseph Eichberg and Cristinel Miinea

15 Docosahexaenoic Acid Therapy for Disorders of Peroxisome Biogenesis 257

Hugo W. Moser and Gerald V. Raymond

16 Effects of Fatty Acids and Ketones on Neuronal Excitability:

Implications for Epilepsy and its Treatment 273

Carl E. Stafstrom

17 Fatty Acid Ethyl Esters:

Toxic Nonoxidative Metabolites of Ethanol 291

Zbigniew M. Szczepiorkowski and Michael Laposata

Part V Psychiatry and Behavior

18 Omega-3 Fatty Acids and Psychiatric Disorders:

Current Status of the Field 311

Joseph R. Hibbeln and Norman Salem Jr.

19 Disorders of Phospholipid Metabolism in Schizophrenia,

Affective Disorders, and Neurodegenerative Disorders 331

David F. Horrobin

20 Eicosapentaenoic Acid:

A Potential New Treatment for Schizophrenia? 345

Malcolm Peet and Shaun Ryles

21 The Importance of DHA in Optimal Cognitive Function in Rodents 357

Claus C. Becker and David J. Kyle

22 The Role of Omega-3 Polyunsaturated Fatty Acids in Body Fluid and Energy Homeostasis 377

Richard S. Weisinger, James A. Armitage, Peta Burns, Andrew J. Sinclair, Algis J. Vingrys, and Harrison S. Weisinger

23 PUFA:

Mediators for the Nervous, Endocrine, and Immune Systems 403

Shlomo Yehuda, Sharon Rabinovitz, and David I. Mostofsky

Glossary 421

Index 425

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