Prior to searching for the genes involved in a disease and determining how those genes work in the various tissues of the human body, there must be clear evidence that genetics is involved in the disease. Genetic analyses are ethically and financially challenging, as well as quite laborious. Geneticists use several methods to evaluate whether or not genetics plays an important role in the etiology of a disorder before they begin a search for a gene. Some of these methods include familial aggregation, recurrence risks, and twin studies.
Familial aggregation can be established by obtaining a thorough family history on study participants. Individuals are simply asked if they have any
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