An inversion is the rotation of a broken chromosome segment in such a way that it rejoins the chromosome in a reversed state, or is flipped, end to end. Inversions are usually characterized by whether the centromere is included in the inverted segment. Inversions containing the centromere are called pericentric. Those not containing the centromere are called paracentric. Although an inversion does not change the overall content of cellular DNA and can be considered a balanced translocation, it can affect a gene at many levels because it alters the normal DNA sequence. The gene may not produce its corresponding protein at all, or a nonfunctioning protein may result. There is a common inversion seen in human chromosomes involving chromosome 9. A small pericentric inversion is present in approximately 1


percent of tested individuals. There appears to be no detrimental effect on the carrier, and it does not appear to cause miscarriage or unbalanced offspring.

100 Pregnancy Tips

100 Pregnancy Tips

Prior to planning pregnancy, you should learn more about the things involved in getting pregnant. It involves carrying a baby inside you for nine months, caring for a child for a number of years, and many more. Consider these things, so that you can properly assess if you are ready for pregnancy. Get all these very important tips about pregnancy that you need to know.

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