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VOLUME 4_

For Your Reference v

List of Contributors xiii

Quantitative Traits 1

Reading Frame 4

Recombinant DNA 5

Repetitive DNA Sequences 7

Replication 12

Reproductive Technology 19

Reproductive Technology: Ethical Issues . 26

Restriction Enzymes 31

Retrovirus 34

Reverse Transcriptase 39

Ribosome 42

Ribozyme 44

RNA 46

RNA Interference 54

RNA Processing 57

Rodent Models 60

Roundworm: Caenorhabditis elegans 62

Sanger, Fred 64

Science Writer 65

Selection 67

Sequencing DNA 69

Severe Combined Immune Deficiency ... 74

Sex Determination 78

Sexual Orientation 83

Signal Transduction 85

Speciation 91

Statistical Geneticist 93

Statistics 95

Tay-Sachs Disease 98

Technical Writer 102

Telomere 104

Transcription 106

Transcription Factors 112

Transduction 117

Transformation 121

Transgenic Animals 124

Transgenic Microorganisms 127

Transgenic Organisms: Ethical Issues .. 129

Transgenic Plants 132

Translation 135

Transplantation 139

Transposable Genetic Elements 143

Triplet Repeat Disease 148

Tumor Suppressor Genes 153

Twins 155

Viroids and Virusoids 162

Virus 164

Watson, James 171

X Chromosome 173

Y Chromosome 176

Yeast 179

Zebrafish 181

Photo Credits 185

Glossary 189

Topical Outline 207

Cumulative Index 213

OOOQOQC

Accelerated Aging: Progeria

Human progeria comes in two major forms, Werner's syndrome (adult-onset progeria) and Hutchinson-Gilford syndrome (juvenile-onset progeria). Werner's patients are usually diagnosed in early maturity and have an average life span of forty-seven years. Hutchinson-Gilford patients are usually diagnosed within the first two years of life and have an average life span of thirteen years. The latter syndrome is often simply termed "progeria" and both are sometimes lumped together as progeroid syndromes.

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