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to preserve genetic variability within a species by allowing for virtually limitless combinations of genes in the transmission from parent to offspring.

The frequency of recombination is not uniform throughout the genome. Some areas of some chromosomes have increased rates of recombination (hot spots), while others have reduced rates of recombination (cold spots). The frequency of recombination in humans is generally decreased near the centromeric region of chromosomes, and tends to be greater near the telo-meric regions. Recombination frequencies may vary between sexes. Crossing over is estimated to occur approximately fifty-five times in meiosis in males, and about seventy-five times in meiosis in females.

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