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Cycle Sequencing 198

Cystic Fibrosis 199

Development, Genetic Control of 204

Diabetes 209

Disease, Genetics of 213

DNA 215

DNA Footprinting 220

DNA Libraries 222

DNA Microarrays 225

DNA Polymerases 230

DNA Profiling 233

DNA Repair 239

DNA Structure and Function, History . 248

DNA Vaccines 253

Down Syndrome 256

Photo Credits 259

? Glossary 263

Topical Outline 281

Index 287

VOLUME 2_

For Your Reference v

List of Contributors xiii

Educator 1

Embryonic Stem Cells 3

Epidemiologist 6

Epistasis 7

Escherichia coli (E. coli bacterium) 9

Eubacteria 11

Eugenics 16

Evolution, Molecular 21

Evolution of Genes 26

Eye Color 31

Fertilization 33

Founder Effect 36

Fragile X Syndrome 39

Fruit Fly: Drosophila 42

Gel Electrophoresis 45

Gene 50

Gene and Environment 54

Gene Discovery 57

Gene Expression: Overview of Control . . 61

Gene Families 67

Gene Flow 70

Gene Targeting 71

Gene Therapy 74

Gene Therapy: Ethical Issues 80

Genetic Code 83

Genetic Counseling 87

Genetic Counselor 91

Genetic Discrimination 92

Genetic Drift 94

Genetic Testing 96

Genetic Testing: Ethical Issues 101

Genetically Modified Foods 106

Geneticist 110

Genetics 111

Genome 112

Genomic Medicine 118

Genomics 120

Genomics Industry 123

Genotype and Phenotype 125

Growth Disorders 129

Hardy-Weinberg Equilibrium 133

Hemoglobinopathies 136

Hemophilia 141

Heterozygote Advantage 146

High-Throughput Screening 149

HIV 150

Homology 156

Hormonal Regulation 158

HPLC: High-Performance Liquid

Chromatography 165

Human Disease Genes, Identification of . 167

Human Genome Project 171

Human Immunodeficiency Virus 178

Huntington's Disease 178

Hybrid Superiority 178

Immune System Genetics 178

Imprinting 183

In situ Hybridization 186

Inbreeding 189

Individual Genetic Variation 191

Information Systems Manager 192

Inheritance, Extranuclear 194

Inheritance Patterns 199

Intelligence 207

Internet 211

Photo Credits 215

Glossary 219

Topical Outline 237

Index 243

VOLUME 3_

For Your Reference v

List of Contributors xiii

Laboratory Technician 1

Legal Issues 3

Linkage and Recombination 4

Mapping 11

Marker Systems 15

Mass Spectrometry 18

McClintock, Barbara 21

McKusick, Victor 22

Meiosis 24

Mendel, Gregor 30

Mendelian Genetics 32

Metabolic Disease 37

Methylation 46

Microbiologist 50

Mitochondrial Diseases 51

Mitochondrial Genome 55

Mitosis 57

Model Organisms 60

Molecular Anthropology 62

Molecular Biologist 70

Morgan, Thomas Hunt 72

Mosaicism 76

Muller, Hermann 80

Multiple Alleles 82

Muscular Dystrophy 83

Mutagen 87

Mutagenesis 89

Mutation 93

Mutation Rate 98

Nature of the Gene, History 101

Nomenclature 106

Nondisjunction 108

Nucleases 112

Nucleotide 115

Nucleus 119

Oncogenes 127

Operon 131

Overlapping Genes 135

Patenting Genes 136

Pedigree 138

Pharmaceutical Scientist 142

Pharmacogenetics and

Pharmacogenomics 144

Physician Scientist 147

Plant Genetic Engineer 149

Plasmid 150

Pleiotropy 153

Polymerase Chain Reaction 154

Polymorphisms 159

Polyploidy 163

Population Bottleneck 167

Population Genetics 171

Population Screening 175

Post-translational Control 178

Prenatal Diagnosis 182

Prion 187

Privacy 190

Probability 193

Protein Sequencing 196

Proteins 198

Proteomics 205

Pseudogenes 209

Psychiatric Disorders 213

Public Health, Genetic Techniques in .. 216

Purification of DNA 220

Photo Credits 223

Glossary 227

Topical Outline 245

Index 251

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