Yeast Artificial Chromosomes

Artificial chromosomes for use in yeast and mammalian cells aim to replicate these components on a single DNA molecule. In bakers yeast (Saccharomyces

Fluorescence in situ hybridization (FISH) visualization of one of the artificial human chromosomes successfully created by investigators at the Case Western Reserve University School of Medicine and Athersys, Inc. The arrow highlights the synthetic microchromosome, a miniature version of the surrounding native human chromosomes. The chromosome material appears dark blue, and the centromeres white.

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