Develop high-throughput bioanalysis
Support optimal drug design c Identifying physicochemical & molecular components that dictate PK î> PK-SAR & PD-SAR Predict if compound will have acceptable PK properties, o is bioavailable after oral administration c is not extensively metabolized o Is target tissue available, e.g., brain penetration for CNS compounds
Rank order chemotypes based on Physicochemical Characteristics predicting favorable exposure
S9 / microsomal stability plasma stability
Select New Chemical Entity (NCE)
Single compound PK preferably in animal model for in wVoconcept testing
Single compound PK in a second species and in species used for toxicity screening
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