(single or multiple doses) o Effect of hepatic impairment upon safety & tolerability of drug o Effect of hepatic impairment upon PK of drug r Rationale for study o Hepatic metabolism or biliary excretion accounts for large portion of parent drug or active metabolite elimination o Drug with narrow TI even if minor hepatic CL o Drug hepatic elimination could become important in event of renal impairment
Ranolazine Day 3
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What you need to know about… Project Management Made Easy! Project management consists of more than just a large building project and can encompass small projects as well. No matter what the size of your project, you need to have some sort of project management. How you manage your project has everything to do with its outcome.