Most Candidates Never Make it to Market

Fig. 4.8. The Problem with Drug Development r Identify new targets for disease intervention r Create new reagents that address important disease targets r Develop essential assays and models r Explore possible surrogate endpoints and biomarkers for use in monitoring clinical trials r Conduct research needed to advance or kill each project promptly r Determine product pharmacokinetics, pharmacodynamics and safety r Coordinate new research to expand indications for existing products r Generate intellectual property to create/enhance product protection

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