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Fig. 9.8a-c. Images from a patient (case 10) with a tentorial mengioma. a Parametric map of rCBV from T2*W data. b Map of Ktrans from T1W data. c Map of ve from T1W data. The tumour shows very low values of rCBV below those of normal grey matter but is conspicuous on both Ktrans and ve maps. Spatial distribution of Ktrans is weakly correlated with ve but not at all with rCBV, with R(k,ve) =0.22, R(k,CBV) = 0.10, respectively

Fig. 9.9a-e. Images from a patient with a posterior falcine meningioma. a,b Pre- and post-contrast image from T1W dynamic series. There is diffuse enhancement of leptomeninges on the post-contrast T1W images. c Parametric map of rCBV from T2*W data. d Map of Ktrans from T1W data. e Map of ve from T1W data. The tumour shows relatively homogeneous distribution of all parameters. The calvarial meninges show marked increase in Ktrans and ve whilst the rCBV map shows no apparent abnormality

Fig. 9.9a-e. Images from a patient with a posterior falcine meningioma. a,b Pre- and post-contrast image from T1W dynamic series. There is diffuse enhancement of leptomeninges on the post-contrast T1W images. c Parametric map of rCBV from T2*W data. d Map of Ktrans from T1W data. e Map of ve from T1W data. The tumour shows relatively homogeneous distribution of all parameters. The calvarial meninges show marked increase in Ktrans and ve whilst the rCBV map shows no apparent abnormality b a c tumour and in apparently normal meninges with normal values of rCBV. These observations suggest that biological decoupling of permeability effects and changes in local blood volume do occur and that independent measures of Ktrans and rCBV may provide different, complementary biological information about the angiogenic process.

metastasis («=8) using a three compartmental model. Grading of gliomas with an accuracy of 73% was achieved based on the vascular volume maps alone. Furthermore, meningiomas and gliomas differed in the voxel patterns plotted in interstitial vs. vascular volume diagrams. Additionally, gliomas showed an increased Ktrans compared to other two tumour types (Ludemann et al. 2002).

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