Intraperitoneal Seeding

It has been classically assumed that transcoelomic spread is a random event or, at least, a function of serosal implantation in the immediate area of a primary neoplasm. However, I have shown that the deposition and growth of secondarily seeded neoplasms in the abdomen depend on the natural flow of ascites within the peritoneal re-cesses.3 A primary neoplasm or even its intraabdominal lymph node metastases, in breaking through into the peritoneal cavity, can shed cells into the ascitic fluid induced. The degree of ascites need not be great for the transportation and deposition of malignant cells. I have documented that intraperitoneal fluid, rather than being static, continually follows a circulation through the abdomen.3,70,94 These dynamic pathways of distribution and sequential spread depend particularly on mesenteric reflections and peritoneal recesses as well as on the forces of gravity and negative subdiaphragmatic pressure.

Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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