Deferoxamine Challenge Test

This test is sometimes performed in cases where toxicity is not clear and laboratory results are still pending (1st 6 h). The patient is given deferoxamine 50 mg/kg up to 1 g IM, and all the urine is collected. If the urine turns a vin rose color, the test is positive and chelation is continued intravenously. However it is important to note that the urine color change is an insensitive marker and that a negative challenge test does not rule out the presence of iron toxicity. For that reason, many toxicologists no longer recommend this test.

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