Rita K. Cydulka Sorabh Khandelwal
Epidemiology Pathophysioloqy ClinicalFeature.s Diagnosis Treatment Adrenergic Agents
Mast Cell Modifiers
Leukotriene, Modifiers Mechanical, .Ventilation
Specific Issues that Impact Diagnosis, Evaluation, and Treatment
Asthma is a chronic inflammatory disorder characterized by increased responsiveness of the airways to multiple stimuli. Many cells and cellular elements, such as mast cells, eosinophils, T lymphocytes, macrophages, neutrophils, and epithelial cells, play a role in the development of the inflammatory response. In susceptible individuals, the inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning. These episodes are usually associated with widespread, but variable, airflow obstruction, that is often reversible either spontaneously or with treatment.
Most acute attacks are reversible and improve spontaneously or within minutes to hours with treatment. Although patients appear to recover completely clinically, evidence suggests that asthmatic patients develop chronic airflow limitation.1 The recognition that asthma is a chronic inflammatory disorder of the airways has significant implications for the diagnosis, management, and potential prevention of its acute exacerbation.
Was this article helpful?
If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.