The major mineralocorticoid is aldosterone. The renin-angiotensin system and plasma potassium concentration regulate aldosterone through negative feedback loops. These mechanisms are probably of equal importance and far more important than the minor aldosterone-stimulating effect of ACTH.

Aldosterone acts to increase sodium reabsorption and potassium excretion, primarily in the distal tubules of the kidneys. Other tissue effects of aldosterone are minor in comparison with its regulation of sodium and potassium levels.

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