Antibiotics, although of questionable utility in the treatment of tetanus, have traditionally been administered. Clostridium tetani is sensitive to a number of antibiotics (e.g., penicillins, cephalosporins, tetracycline, and erythromycin), but parenterally administered metronidazole should be considered the antibiotic of choice. 13 Penicillin, a centrally acting GABAa antagonist may potentiate the effects of tetanospasmin, and therefore its use should be avoided.1

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