Antipsychotics

Richard A. Harrigan William J. Brady

Pharmacology

Adverse .Effects Extrapyramidal,. Disorders

Tardive „Dyskinesia

Miscellaneous, Adverse,, Effects

Acute,, Overdose

Treatment

Disposition

Chapter, References

A group of antipsychotic drugs, classically termed neuroleptics, have been in use since the 1950s for the treatment of schizophrenia and other related psychoses

(Table 1.5.5-.1)- Although they have revolutionized the treatment of these disorders, these agents are known to cause myriad adverse effects, both in therapeutic and toxicologic situations. A propensity to affect neurologic function led to the term neuroleptic, which is less appropriate today in light of the development of newer agents for the treatment of schizophrenia that are less likely to cause these effects; thus, these agents are now usually classified as antipsychotic agents (see Table 1.5.5-1).

In addition to the treatment of various psychoses, however, these drugs also are used for nonpsychiatric conditions, such as chemical restraint of agitated or violent patients; control of nausea and emesis; pain and nausea relief in various headache syndromes; suppression of hiccups; and control of various involuntary motor disorders, including Tourette's syndrome, Huntington's chorea, and various disorders of the basal ganglia.

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