Aortic Dissection And Aneurysms

Gary A. Johnson Pathogenesis





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ThoracicAo^riic, Aneurysm Dissecting^ortic Aneurysms


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Aortic,, Dissection Chapter, References

Thoracic and abdominal aneurysmal disease comprises a significant subset of emergencies. A ruptured aneurysm or dissecting aneurysm is a prominent cause of sudden death as well as severe abdominal, chest, or back pain. These diseases disproportionately affect the elderly. As our patient population becomes older, the incidence of presentations for aneurysms will continue to increase.1,2 and 3

Abdominal aortic aneurysms (AAA) have a clear familial trend. Eighteen percent of patients with AAA have a family history of aneurysm (a first-degree relative) compared with less than 3 percent of controls. Patients with Marfan syndrome have been found to have mutations in the FBN1 gene on chromosome 15.2 Other genetic abnormalities have been investigated as well.23

The incidence of AAA increases with age and rarely presents before age 50. Most patients are older than 60 and males have an increased risk of disease. Patients with other aneurysms and peripheral arterial disease are at an increased risk as well.

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