Arsine is a colorless, nonirritating gas encountered in the semiconductor industry, ore smelting, and refining processes and is also produced when arsenic-containing insecticides are mixed with acids. Arsine attaches to sulfhydryl groups of hemoglobin, producing an acute hemolytic anemia with resulting jaundice, abdominal pain, and hemoglobinuria-induced acute renal failure. Acute poisonings are managed with blood transfusions, exchange transfusion to remove the nondialyzable arsine, and hemodialysis for the acute renal failure. BAL therapy has no role in the management of arsine toxicity.
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