BBlocker Toxicity

William P. Kerns II

Physiology Toxicophysiology

Pharmacolo„qy„and.Pha„Bffl.ac.okine.ti.cs

ClinicalPresentation

Diagnosis

Diaqnpstic.Studies

Treatment

Disposition Chapter, .References b-adrenergic receptor antagonists, or b-blockers, alleviate such manifestations of cardiovascular disease as hypertension, tachydysrhythmias, and myocardial infarction. Considering the high prevalence of cardiovascular disease and the widespread use of b-blockers, it is not surprising that accidental and intentional poisoning is common. Poison control center data from 1996 demonstrate over 7200 exposures to b blockers. Of these, 134 were serious poisonings, resulting in 16 deaths.1 These data probably underestimate the true prevalence of b-blocker toxicity due to underreporting of poisonings.

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